Select the airframe configuration for your vehicle brand and model, if one exists, as this should be tuned well enough to fly following standard configuration. Otherwise select the closest "Generic" frame option.
To set the airframe:
Start QGroundControl and connect the vehicle.
Select "Q" icon > Vehicle Setup > Airframe (sidebar) to open Airframe Setup.
The example above shows Generic Hexarotor X geometry selected from the Hexarotor X group.
Click Apply and Restart. Click Apply in the following prompt to save the settings and restart the vehicle.